U.S. Covid-19 vaccination rates are heavily influenced by the legacy of centuries-old colonization patterns. Value differences between the regional cultures created by these rival colonization campaigns shape the behavior of elected officials and the general public.

For those with an interest in the regional model set forth in American Nations: A History of the Eleven Rival Regional Cultures of North America, here are population figures for the U.S. portions of each of the nations as per the 2020 census and the rate of growth or loss for each since the 2010 census.

For several years now, political journalists, analysts, and pundits have been arguing that U.S. politics has increasingly turned into a struggle between urban and rural voters. Regional differences were once paramount, Josh Kron observed in the Atlantic after the 2012 election.